https://www.acpuchades.com/tags/outcome-measures/Recent content in Outcome Measures on Alejandro Caravaca PuchadesHugo -- gohugo.ioen© 2026 Alejandro Caravaca PuchadesMon, 11 May 2026 00:00:00 +0000https://www.acpuchades.com/blog/alsfrs-critical-appraisal-part-ii/Mon, 11 May 2026 00:00:00 +0000https://www.acpuchades.com/blog/alsfrs-critical-appraisal-part-ii/A structured tour of the ALSFRS-R: its twelve items across four functional domains, why feasibility and sensitivity to change made it the field’s standard outcome measure for twenty-five years, and a frank account of the psychometric limitations that have accumulated against it.https://www.acpuchades.com/blog/alsfrs-critical-appraisal-part-i/Tue, 05 May 2026 00:00:00 +0000https://www.acpuchades.com/blog/alsfrs-critical-appraisal-part-i/Clinical trials in ALS live or die by their outcome measures. This opening piece of the series frames the measurement problem in neurodegeneration — biological versus functional endpoints — and sets up why the ALSFRS-R became the field’s default answer to it.